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Functionally Graded Additive Manufacturing Scaffolds by Hybrid Manufacturing

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Partners

  • Abalonyx AS (Norway)

    Abalonyx is a Norwegian SME engaged in R&D related to graphene derivative nanoparticulate materials and functional coatings based on graphene derivatives. The company was founded in 2005, and has four full time employees. The company is owned by founder Dr. Rune Wendelbo and Kongsberg Innovation, and is based in Oslo, Norway with factory in Tofte, Norway.

    On the R&D side we are specialized in the synthesis and surface functionalization of inorganic nano-particles, with focus on graphene and derivatives of graphene, which we have been working on since 2008. On the methods side we use and develop automated, high throughput methods based on the standard well-plate format. The aim is to employ parallelization and automation in all aspects of experimental work, in order to secure quality and reproducibility. Abalonyx is now scaling up production and commercializing its graphene oxide products, primarily graphene oxide and reduced graphene oxide.

  • Fraunhofer IST (Germany)

    As an innovative R&D partner the Fraunhofer Institute for Surface Engineering and Thin Films IST offers complete solutions in surface engineering which are developed in cooperation with customers from industry and research. The IST's "product" is the surface, optimized by modification, patterning, and/or coating for applications in the business units automotive, tools and mechanical engineering, aerospace, energy and electronics, optics, and also life science and ecology.

    The principle technology units at the IST are atmospheric pressure processes with the main focus on electrochemical processes and atmospheric pressure plasmas processes, low pressure plasma processes with the main focus on magnetron sputtering and highly ionized plasmas and PECVD as well as chemical vapor deposition with the main focus on hot-wire CVD. The center of tribological coatings focusses on the friction reduction, wear and corrosion protection. The Application Center for Plasma and Photonics deals with mobile plasma sources and laser plasma hybrid processes.

    The IST's expertise lies in the ability to control all of the above-mentioned processes and their combination with a great variety of thin films. Extensive experience with thin-film deposition and film applications is complemented by excellent capabilities in surface analysis using the very latest equipment and in simulating vacuum-based processes.

    Choosing the optimum combination of process and coating for a particular task is one of the major strengths of the Fraunhofer IST. Besides fundamental research activities in cooperation with universities and research centers, about 120 employees are developing tailored surfaces and processes together with service providers, equipment manufacturers, and coating users from diverse industries. For an efficient technology transfer the IST offers a broad range of services, from development of prototypes and economical product scenarios to upscaling and even implementation of the technology at the customer.

  • Gesellschaft fuer Silizium-Mikrosysteme mbH (Germany)

    GeSiM was founded 1995 as a spin-off from the Rossendorf Research Center. The company is a non-public and privately held entity. Building upon a broad expertise in micromachining technologies, GeSiM has evolved into a bioinstrumentation company focusing on submicroliter liquid handling instruments, microfluidics and micro contact printing.

    As a leading supplier of submicroliter dispensers GeSiM developed benchtop pipetting system Nano-Plotter used for the production of (FDA) certified diagnostic products. Liquid handling by contact printing is available with the micro-contact printers from GeSiM. Recent developments are focused on instrumentation for 3D printing of biocompatible materials, e.g bioscaffolds for regenerative medicine.

    The latest development is a compact synthesis station for radiochemistry, which combines liquid handling, solids handling, reaction engineering. These systems perform autonomously radio synthesis in commercial available hotcells on the basis of the GMP standards.

  • Maastricht University (Netherlands)

    The department of Complex Tissue Regeneration (CTR) is one of the founding fathers of the new MERLN Institute for technology inspired regenerative medicine at Maastricht University.

    Research and Innovation activities of the FAST project will be carried out at CTR. The department holds a prominent international position in the regeneration of vascular, bone and cartilage tissue, however, definitely not only limited to these topics. Biofabrication technologies, among which additive manufacturing, played a key role in the strategies developed by the department in the past 15 years. The groups' efforts focus on development of polymeric, ceramic and composite scaffolds, improvement of cell and growth factor based tissue engineering, design of high-throughput screening methods and bioreactors with the goal of improving methods for complex tissues and organ regeneration.

    The CTR department has modern and fully equipped laboratories dedicated to tissue engineering and regenerative medicine in its broadest sense, ranging from cell biological, materials and technological perspective. Cell culture facilities including ML-2 level for viral transduction of cells are available as well as fully operational in house developed bioreactor set ups. Furthermore, CTR houses histology, cellular, and molecular biology labs, and has access to atomic force, transmission and scanning electron, and confocal microscopes. Biomaterials facilities include equipment for surface modifications, chemical, thermal, and mechanical analysis, and a number of technologies for scaffold fabrication and characterization. When appropriated and conforming to national and European laws, the newly developed cell and materials technologies can be tested in vivo in dedicated animal facilities.

    CTR has long standing collaborations with several clinical groups within The Netherlands, as well as internationally. In the FAST project, CTR will be involved in the activities for the design and fabrication of the new additive manufacturing technologies, as well as in the fabrication of scaffolds for bone regeneration. The biofabrication group led by Dr. Lorenzo Moroni will be coordinating the project and the different activities proposed.

  • Nadir SRL(Italy)

    Nadir is a small enterprise established in 2008 by a group of colleagues of CIVEN (a technological transfer center in the Venice area) joined by the common aim of developing and bringing a proprietary new technology in the market: a novel atmospheric plasma device.

    Thanks also to several regional and European project funding, the goal has been achieved in 2014 and the new plasma jet has been patented and commercialized. The new tool, characterized mainly by high efficiency and low processing temperature and no electrodes deposition, find interesting applications on sensitive substrates or where no process poisoning is acceptable.

    In 2016 the company extended its competences also in polymers compounding in order to offer to her customers a complete consultancy approach: bulk and surface properties tailoring. An operating site and lab equipped with atmospheric plasma devices and twin-screw extruder inside the University of Venice Scientific Campus allows to offer a scientific approach to solve customer needs.

  • Polyvation BV (Netherlands)

    PolyVation is specialized in research, development, manufacturing and analysis of customized biomedical polymers for advanced applications in healthcare, such as implants, coatings, tissue engineering scaffolds and drug delivery depots.

    PolyVation's organization is ISO 13485 certified. Our manufacturing operations are being performed under a stringent quality regime corresponding to the industry guidelines of the EU and FDA (US) for the manufacturing of active pharmaceutical ingredients, excipients and medical devices (Q7, 21 CFR 820 / ISO 13485). PolyVation works with highly educated and experienced people in an advanced laboratory and production environment including class 8 clean rooms. The company is located in Groningen, The Netherlands and employs nowadays over 50 employees in total.

  • Prolabin & Tefarm SRL (Italy)

    PROLABIN & TEFARM S.r.l. (P&T) is born as spin-off company from the University of Perugia (Italy) after about 40 years of academic research in the field of inorganic layered solids with the aim of transfer the knowledge e the technologies in the market. P&T develops, produces and sells non conventional, often biocompatible, layered inorganic and inorgano-organic fillers and additives in the form of micro and nanopowders. These innovative additives belong to the class of synthetic hydrotalcites and phosphates/phosphonates of polyvalent metals (mainly zirconium and titanium), opportunely modified with molecular inorganic or organic ions required to confer to the fillers peculiar characteristics. The operation strategy is based on the ability of dealing with materials tailor made for the customer's requirements according these two business areas:

    1) Synthesis and marketing of fillers and additives of polymeric matrices (polyolefins, polyesters, rubbers) to obtain polymeric nanocomposites

    2) Synthesis and marketing of modified biocompatible hydrotalcites for companies dealing with pharmaceutical health care and cosmetics.

    P&T additives are non conventional nanofillers that compare favourably with nanoclays because of higher purity, synthesis reproducibility, size and aspect ratio control, higher possibility of modification through intercalation of functional species. These innovative additives can be directly added during the normal productive cycle without any modification of the original plant and preserving the good homogeneity of the composite materials.

    The interlamellar region is a nano-vessel in which host species are stored, protected (by oxidation, photolysis and hydrolysis) and released at proper time. The inclusion of active species into anionic clay modifies the release conditions and increases the apparent solubility, the bioavailability and the photostability.

  • tecnalia (Spain)

    Tecnalia Research & Innovation is the largest private Research, Development and Innovation (R+D+i) group in Spain and one of the leading ones in Europe, with a staff of over 1,400 people. Its mission is to transform knowledge into GDP, improving people's quality of life by generating business opportunities for companies. TECNALIA masters advanced technologies in areas like: sustainable construction, ICT, Energy & Environment, Industry and transport, innovation and society, health.

  • University of Padova (Italy)

    The University of Padua, located in Padua, Italy, was founded in 1222. It is among the earliest of the universities in the world and the second oldest in Italy and it has more than 40.000 students. The Department of Physics and Astronomy has been involved in the project since from February 2016 Alessandro Patelli, FAST Scientific coordinator, has been hired by the University and he is part of the Nanostructures Group. Partner's role is therefore the support to coordination and to plasma devices and processes development, masterbatches development and on characterisation issues.

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Last modified on:
2017-02-03 11:10:51 CET
Author:
Sabrina Kühne <info@inplas.de>
Source:
http://project-fast.eu/en/partners
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